PVM : Presentation
The Montpellier Vectorology Platform (PVM) is dedicated to the production of recombinant viral particles for any requesting laboratory. Viral vectors enable efficient, reproducible, and targeted gene expression in various cell types.
The particles produced by PVM are based on several viral systems:
- Human and canine adenoviruses
- Lentivirus / Retrovirus
- Adeno-Associated Viruses (AAV)
The use of adenoviruses, AAVs, or lentiviruses has advantages and limitations linked to the intrinsic properties of each vector, including:
- Their episomal (non-integrating) or integrative nature,
- The onset and duration of transgene expression,
- Their cellular tropism, broad or specific,
- The size of the genetic material that can be delivered.
These particles can infect cell lines, primary cultures, and/or be injected directly in vivo. All these factors must be considered to choose the vector best suited for a project.
Our Missions
Applications
- Labeling of specific cell cohorts, lineage, and network studies
- Control of neuronal activity
- Gain- and loss-of-function approaches to identify the role of different genes
- Vaccines
- Gene therapy
